Pica anemia antioxidant capacity selenium zinc. These effects should be kept in mind while managing patients with pica. Consequently, it is thought that the detrimental effects of pica within the organism were mediated by adverse impacts on antioxidant capacity and oxidative stress. Comparison of pica and IDA groups yielded significantly lower levels of total antioxidant levels and significantly higher oxidative stress index in the pica group. Total oxidant levels were highest in the pica group and consistently, the lowest total antioxidant capacity was observed again in the pica group. The results demonstrated significantly lower levels of serum selenium and zinc in pica and IDA groups compared to the control group. The present study evaluated the effects of pica and IDA on oxidative stress and antioxidant capacity as well as on the levels of trace elements including serum zinc and selenium in 47 children with IDA plus pica, 22 children with IDA only and 21 nonanemic children as controls. The effect of pica on oxidative stress and antioxidant capacity has not been investigated yet. The literature contains contracting data on the levels of oxidative stress and antioxidant levels in patients with iron-deficiency anemia (IDA). There are a few studies on serum trace element levels of patients with pica. Our hope in naming this relatively unexplored symptom associated with IDA will encourage additional clinicians to share their experience and guide future investigation.Pica is defined as developmentally inappropriate consumption of nonnutritive substances for at least 1 month. "Desidero" can also be indicative of a reduction in iron, which relates to iron deficiency. For this, we propose the term "desideromastica" derived from the Latin words "desiderare" for desire and "mastica" for chew. Our patient experience provides suggestive evidence that oral tactile craving symptoms, distinct from ice pica, exists in a subset of patients suffering from IDA. The lone patient with persistent symptoms had a baseline ferritin of 10 µg/L, improved to 398 µg/L after replacement, and settled back at 42 µg/L three months later. Overall, 88.9% (8/9) reported resolution of chew cravings after iron repletion. Post-treatment median laboratory values include: Hgb 12.7 g/dL (10.8-14.7), MCV 80.1 fL (76.1-91.7), and ferritin 98 µg/L (24-398). Pica occurs in up to 60 per cent of patients with iron-deficiency anaemia when it typically manifests in the form of a craving for ice, which is called. Oral (ferrous glyconate or ferrous fumarate) and intravenous (ferric carboxymaltose, iron sucrose, or low molecular weight iron dextran) iron replacement were used in 33.3% (3/9) and 66.7% (6/9) patients, respectively. In total, 9 patients proceeded with observed treatment of their IDA with clinical follow-up and laboratory confirmation of iron repletion. Only 16.7% (2/12) reported concurrent ice pica. Many patients reported the frequency and satisfaction of these cravings resulted in jaw pain as well as the persistence of cravings despite this discomfort. Tactile cravings included chewing gum (3), mastic gum (2), ginseng (1), dry oats (1), crackers (1), pickles (1), chips (1), sawdust (1), and knitting rope (1). All patients were female and the median age was 41.5 years (33-59). We observed 12 patients with IDA who self-reported chew cravings during initial evaluation. Information including sociodemographics, substance craved, values of hemoglobin (Hgb), mean corpuscular volume (MCV), and ferritin before and after iron replacement therapy, and symptom resolution after treatment were recorded. This study included patients from the Mayo Clinic (Rochester, MN) and Ankara Training and Research Hospital (Ankara, Turkey) Hematology practices who self-reported tactile mastication cravings during initial evaluation for IDA between 1/1/18 and 6/30/19. In our practice we observed a subset of patients with IDA who report specific tactile cravings associated with mastication. Olfactory cravings associated with IDA are a recently described phenomenon known as desiderosmia. The compulsive craving and consumption of non-food substances, known as pica, is a well-documented symptom associated with iron deficiency anemia (IDA).
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